6533b7d9fe1ef96bd126cce9
RESEARCH PRODUCT
Hormonal and nutritional control of L‐carnitine uptake in myoblastic C2C12 cells
Caroline RigaultBéatrice GeorgesJean DemarquoyFrançoise Le Borgnesubject
medicine.medical_specialtyIron OverloadOrganic Cation Transport ProteinsBioenergeticsPhysiologymedicine.medical_treatmentBiologyCell LineCellular and Molecular NeuroscienceCarnitinePhysiology (medical)Internal medicinemedicineHumansInsulinNutritional Physiological PhenomenaRNA MessengerCarnitineMuscle SkeletalSolute Carrier Family 22 Member 5InsulinThyroidSkeletal muscleMetabolismBlotting NorthernHormonesmedicine.anatomical_structureEndocrinologyTriiodothyronineNeurology (clinical)Iron CompoundsEndocrine glandHormonemedicine.drugdescription
L-Carnitine plays an important role in skeletal muscle bioenergetics, and its bioavailability and thus its import may be crucial for muscle function. We studied the effect of thyroid hormone, insulin, and iron overload, hormones and nutrients known to alter muscle metabolism, on L-carnitine import into C2C12 cells. We report here L-carnitine uptake is increased by thyroid hormones and decreased by iron. Insulin was found to be ineffective in altering the L-carnitine uptake.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-05-30 | Muscle & Nerve |