6533b7d9fe1ef96bd126ccf8

RESEARCH PRODUCT

Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

Rafael AlósDulce C Macias-cejaMaria D. BarrachinaDolores Ortiz-masiáL Gisbert-ferrándizJuan V. EspluguesFrancisco NavarroSara CalatayudFrancisco CanetJesus Cosin-roger

subject

0301 basic medicineautophagyStimulationInflammationDiseaseIntestinal fibrosis03 medical and health sciencesMice0302 clinical medicineCrohn DiseaseFibrosismedicineintestinal fibrosisMurine colitisAnimalslcsh:QH301-705.5Sirolimusbusiness.industryBrief ReportAutophagyGeneral MedicineFibroblastsmedicine.diseaseFibrosisIntestinesMice Inbred C57BLDisease Models Animal030104 developmental biologylcsh:Biology (General)inflammationCancer research030211 gastroenterology & hepatologyCollagenmedicine.symptomComplicationbusinessImmunosuppressive Agents

description

We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis.

yearjournalcountryeditionlanguage
2019-09-01Cells
10.3390/cells8091078https://www.mdpi.com/2073-4409/8/9/1078