Cytotoxic activity of some natural and syntetic sesquiterpene lactones

6533b7d9fe1ef96bd126cd1b

RESEARCH PRODUCT

Cytotoxic activity of some natural and syntetic sesquiterpene lactones

Kenneth F. Bastow Antonella Maggio Rosa Angela Raccuglia Maurizio Bruno Kuo Hsiung Lee Chin Chung Wu Sergio Rosselli

subject

Stereochemistry Substituent Pharmaceutical Science Centaurea Pharmacognosy Sesquiterpene Aldehyde ANTITUMOR AGENTS Analytical Chemistry chemistry.chemical_compound Inhibitory Concentration 50 Lactones Structure-Activity Relationship Cell Line Tumor Drug Discovery Structure–activity relationship Organic chemistry Cytotoxic T cell Humans CENTAUREA-PAUI Cytotoxicity Pharmacology chemistry.chemical_classification Biological Products Molecular Structure DERIVATIVES Organic Chemistry CNICIN Settore CHIM/06 - Chimica Organica Antineoplastic Agents Phytogenic Complementary and alternative medicine chemistry Molecular Medicine Sesquiterpenes Lactone

description

Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.

year	journal	country	edition	language
2006-01-06

10.1055/s-2005-873139 http://hdl.handle.net/10447/5499

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