6533b7d9fe1ef96bd126cd4b
RESEARCH PRODUCT
Longevity: Lesson from model organisms
Nello GrassiMario G. MirisolaAntonio RussoGiusi TaorminaSalvatore VieniFederica Ferrantesubject
0301 basic medicineAginglcsh:QH426-470Settore MED/06 - Oncologia Medicamedia_common.quotation_subjectved/biology.organism_classification_rank.speciesLongevityReviewBiologySignal transductionSettore MED/08 - Anatomia PatologicaModels Biologicalmodel systems03 medical and health sciences0302 clinical medicineModel systemYeastsGeneticsAnimalsHumansHealthy agingSettore MED/49 - Scienze Tecniche Dietetiche ApplicateModel organismGeneGenetics (clinical)Cellular Senescencemedia_commonMammalsved/biologyLongevityEukaryotalcsh:GeneticsSettore MED/18 - Chirurgia Generale030104 developmental biologyEvolutionary biologyHuman longevityModels AnimalDrosophilaMolecular senescence030217 neurology & neurosurgeryBiomarkersdescription
Research on longevity and healthy aging promises to increase our lifespan and decrease the burden of degenerative diseases with important social and economic effects. Many aging theories have been proposed, and important aging pathways have been discovered. Model organisms have had a crucial role in this process because of their short lifespan, cheap maintenance, and manipulation possibilities. Yeasts, worms, fruit flies, or mammalian models such as mice, monkeys, and recently, dogs, have helped shed light on aging processes. Genes and molecular mechanisms that were found to be critical in simple eukaryotic cells and species have been confirmed in humans mainly by the functional analysis of mammalian orthologues. Here, we review conserved aging mechanisms discovered in different model systems that are implicated in human longevity as well and that could be the target of anti-aging interventions in human.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-07-01 |