6533b7d9fe1ef96bd126cdce

RESEARCH PRODUCT

Efficacy and safety of combined diclofenac 0.1 % and gentamicin 0.3 eyedrops after phacoemulsification

Nicola OrzalesiLuca RossettiLuciano BonomiSalvatore CillinoDaniele MonrealeFrancesco PonteRoberto Bellucci

subject

MaleDiclofenacAdministration Topicalmedicine.medical_treatmentEye diseaseEye Infections BacterialDiclofenacDouble-Blind MethodmedicineHumansAgedRetrospective StudiesAntibacterial agentAged 80 and overEndophthalmitisPhacoemulsificationbusiness.industryAnti-Inflammatory Agents Non-SteroidalAminoglycosideEye dropPhacoemulsificationMiddle Agedmedicine.diseaseSensory SystemsAnti-Bacterial AgentsClinical trialOphthalmologyTreatment OutcomeAnesthesiaDrug Therapy CombinationFemaleSurgeryGentamicinGentamicinsOphthalmic SolutionsSafetybusinessmedicine.drug

description

To study the efficacy of combined diclofenac 0.1% and gentamicin 0.3% (Digen) eyedrops to treat postoperative inflammation and prevent ocular infection in eyes having phacoemulsification.Department of Ophthalmology, University of Milan, San Paolo Hospital, Milan; Eye Clinic, University of Verona; and Department of Ophthalmology, University of Palermo, Italy.This double-masked, randomized, clinical trial comprised 90 patients; 45 received Digen and 45, gentamicin 0.3% eyedrops. The main outcome measure of the study was the reduction in signs and symptoms of inflammation, graded on a four-point scale. Also assessed were the presence of bacteria in the conjunctival swab and the proportion of patients requiring additional medication.Digen was more effective in reducing postoperative inflammation than gentamicin alone (P.01). No statistically significant between-group difference was found regarding antibacterial activity. Both treatments were well tolerated throughout the study.Digen seemed to maintain the properties and activities of each individual drug, making it a promising treatment for reducing inflammation after phacoemulsification.

yearjournalcountryeditionlanguage
1997-06-01Journal of Cataract and Refractive Surgery
https://doi.org/10.1016/s0886-3350(97)80285-4