6533b7d9fe1ef96bd126ce21
RESEARCH PRODUCT
On the Use of Metal Purine Derivatives (M=Ir, Rh) for the Selective Labeling of Nucleosides and Nucleotides
Miguel A. SierraMamen Martín-ortizMarta ValenciaCarmen Ramírez De ArellanoMar Gómez-gallegosubject
PurineMetalationIridiumCatalysisNucleobasechemistry.chemical_compoundOrganometallic CompoundsOrganic chemistryMoietyRhodiumNucleotideNuclear Magnetic Resonance BiomolecularPurine NucleotidesAnthraceneschemistry.chemical_classificationPyrenesMolecular StructureOrganic ChemistryCationic polymerizationPurine NucleosidesGeneral ChemistryCombinatorial chemistryFerrocenechemistryAlkynesNucleosidedescription
The reactions of neutral or cationic IrIII and RhIII derivatives of phenyl purine nucleobases with unsymmetrical alkynes produce new metallacycles in a predictable manner, which allows for the incorporation of either photoactive (anthracene or pyrene) or electroactive (ferrocene) labels in the nucleotide or nucleoside moiety. The reported methodology (metalation of the purine derivative and subsequent marker insertion) could be used for the postfunctionalization and unambiguous labeling of oligonucleotides.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-02-23 | Chemistry - A European Journal |