0000000000343941
AUTHOR
Mamen Martín-ortiz
On the Use of Metal Purine Derivatives (M=Ir, Rh) for the Selective Labeling of Nucleosides and Nucleotides
The reactions of neutral or cationic IrIII and RhIII derivatives of phenyl purine nucleobases with unsymmetrical alkynes produce new metallacycles in a predictable manner, which allows for the incorporation of either photoactive (anthracene or pyrene) or electroactive (ferrocene) labels in the nucleotide or nucleoside moiety. The reported methodology (metalation of the purine derivative and subsequent marker insertion) could be used for the postfunctionalization and unambiguous labeling of oligonucleotides.
The selective synthesis of metallanucleosides and metallanucleotides: a new tool for the functionalization of nucleic acids.
Nucleobases team up: the efficient and selective preparation of purine-derived metallanucleosides, metallanucleotides, and metalladinucleotides having M-C bonds (M=Ir(III), Rh(III)) is reported for the first time. The results presented may be applied to the synthesis of functionalized nucleic acids, or DNA/RNA-modified segments.
CCDC 952797: Experimental Crystal Structure Determination
Related Article: Marta Valencia, Mamen Martín-Ortiz, Mar Gómez-Gallego, Carmen Ramírez de Arellano, Miguel A. Sierra|2014|Chem.-Eur.J.|20|3831|doi:10.1002/chem.201304091
CCDC 952795: Experimental Crystal Structure Determination
Related Article: Marta Valencia, Mamen Martín-Ortiz, Mar Gómez-Gallego, Carmen Ramírez de Arellano, Miguel A. Sierra|2014|Chem.-Eur.J.|20|3831|doi:10.1002/chem.201304091
CCDC 952796: Experimental Crystal Structure Determination
Related Article: Marta Valencia, Mamen Martín-Ortiz, Mar Gómez-Gallego, Carmen Ramírez de Arellano, Miguel A. Sierra|2014|Chem.-Eur.J.|20|3831|doi:10.1002/chem.201304091
CCDC 952794: Experimental Crystal Structure Determination
Related Article: Marta Valencia, Mamen Martín-Ortiz, Mar Gómez-Gallego, Carmen Ramírez de Arellano, Miguel A. Sierra|2014|Chem.-Eur.J.|20|3831|doi:10.1002/chem.201304091