6533b7d9fe1ef96bd126cecd

RESEARCH PRODUCT

Delineating margins of lentigo maligna using a hyperspectral imaging system

Noora Neittaanmäki-perttuOlli SakselaAnnamari RankiMari GrönroosLeila JeskanenErna SnellmanIlkka Pölönen

subject

MalePathologySkin NeoplasmsHyperspectral imaginghyperspectral imagingSURGERYLentigo malignaHutchinson's Melanotic Freckle030207 dermatology & venereal diseases0302 clinical medicinelentigo maligna melanomaImage Processing Computer-AssistedPhotographyMelanomaAged 80 and overtumour margin assessmentMelanomaBiopsy NeedleHyperspectral imagingGeneral MedicineImmunohistochemistry3. Good healthTumour margin assessment030220 oncology & carcinogenesisDisease ProgressionFemaleRadiologylentigo malignamedicine.symptomDiagnostic Imagingmedicine.medical_specialtyDermoscopyDermatologyLentigo malignaSensitivity and SpecificitySampling StudiesDiagnosis DifferentialLesion03 medical and health sciencesMANAGEMENTmedicineHumansCONFOCAL MICROSCOPYALGORITHMLentigo maligna melanomaAgedSKIN-CANCERbusiness.industryLentigo maligna melanomaCAREmedicine.disease3121 General medicine internal medicine and other clinical medicineHistopathologybusiness

description

Lentigo maligna (LM) is an in situ form of melanoma which can progress into invasive lentigo maligna melanoma (LMM). Variations in the pigmentation and thus visibility of the tumour make assessment of lesion borders challenging. We tested hyperspectral imaging system (HIS) in in vivo preoperative delineation of LM and LMM margins. We compared lesion margins delineated by HIS with those estimated clinically, and confirmed histologically. A total of 14 LMs and 5 LMMs in 19 patients were included. HIS analysis matched the histopathological analysis in 18/19 (94.7%) cases while in 1/19 (5.3%) cases HIS showed lesion extension not confirmed by histopathology (false positives). Compared to clinical examination, HIS defined lesion borders more accurately in 10/19 (52.6%) of cases (wider, n=7 or smaller, n=3) while in 8/19 (42.1%) cases lesion borders were the same as delineated clinically as confirmed histologically. Thus, HIS is useful for the detection of subclinical LM/ LMM borders. Key words: lentigo maligna; lentigo maligna melanoma; tumour margin assessment; hyperspectral imaging. peerReviewed

yearjournalcountryeditionlanguage
2014-11-15
https://publons.com/wos-op/publon/27886369/