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RESEARCH PRODUCT
A new pericentric inv(8) in acute nonlymphocytic leukemia.
F. FabbianoP. CarboneFabio CaradonnaA. SantoroF. CaroniaS. Mirtosubject
Cancer ResearchBiologychromosome Acute nonlymphocytic leukemia cytogeneticshemic and lymphatic diseasesGeneticsmedicineHumansMolecular BiologyGeneChromosomal inversionZinc fingerGeneticsChromosomal fragile siteChromosomeMiddle Agedmedicine.diseaseMolecular biologySettore BIO/18 - GeneticaLeukemiaLeukemia Myeloid Acutemedicine.anatomical_structureKaryotypingChromosome InversionFemaleBone marrowChromosomes Human Pair 8description
Abstract Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX46,XX,inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-03-01 | Cancer genetics and cytogenetics |