Oksidatīvās fosforilēšanas sistēmas funkcionalitātes novērtēšana, izmantojot citoplazmātisko hibrīdu šūnu modeļus

6533b7d9fe1ef96bd126d0e5

RESEARCH PRODUCT

Oksidatīvās fosforilēšanas sistēmas funkcionalitātes novērtēšana, izmantojot citoplazmātisko hibrīdu šūnu modeļus

subject

OXPHOS sistēma mitohondriālās slimības mitohondriju funkcionalitātes novērtēšana citoplazmatiskie hibrīdi šūnu dzīvotspēja Bioloģija

description

Mitohondriju iekšējā membrānā ir izvietoti pieci enzīmu kompleksi, kas veido oksidatīvās fosforilēšanas (OXPHOS) sistēmu. OXPHOS sistēma saražo līdz pat 90% adenozīntrifosfāta šūnās. Mitohondriālās DNS (mtDNS) mutāciju izraisīti traucējumi OXPHOS sistēmā var izraisīt smagas mitohondriālās slimības. Mitohondriālo slimību diagnosikā nav vienas konkrētas metodes. Patogēno mtDNS mutāciju ietekmi var pētīt izmantojot citoplazmatisko hibrīdu šūnu modeļus. Darba mērķis ir novērtēt OXPHOS funkcionalitāti citoplazmatisko hibrīdu šūnu līniju kontroles grupā un pacienta šūnu līnijā ar iespējami patogēnu mtDNS mutāciju. Tika izveidota šūnu līniju kontroles grupa un noteiktas OXPHOS enzīmu aktivitātes, pielāgots šūnu dzīvotspējas noteikšanas protokols un noteikta šūnu dzivotspēja kontroles grupā, tika raksturota un analizēta šūnu līnija, kas satur mutāciju m.14894T>C, kā arī noteikta mutācijas m.14894T>C izplatība veselu Latvijas iedzīvotāju populācijā.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/51658

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