6533b7d9fe1ef96bd126d5a8
RESEARCH PRODUCT
Modulatory control by non-competitive agonists of nicotinic cholinergic neurotransmission in the central nervous system
Hannsjörg SchröderAndré SchrattenholzAlfred Maelickesubject
General NeurosciencePharmacologyBiologyNicotinic agonistGanglion type nicotinic receptorMuscarinic acetylcholine receptor M5Muscarinic acetylcholine receptormedicineAlpha-4 beta-2 nicotinic receptorReceptorNeuroscienceAcetylcholineAcetylcholine receptormedicine.drugdescription
Abstract Several exogenous and endogenous compounds have been discovered that act on nicotinic acetylcholine receptors as non-competitive agonists (NCA) of low efficacy, and probably also as allosteric regulators of the receptor's sensitivity to acetylcholine. Nicotinic NCAs may be viewed as another facet in the increasingly complex picture of vertebrate brain organization, i.e. they may be part of a higher level ‘chemical’ network that overlays the neuronal network of the CNS. Furthermore, exogenous NCAs may provide a new therapeutic approach to Alzheimer's dementia.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-04-01 | Seminars in Neuroscience |