6533b7d9fe1ef96bd126d700
RESEARCH PRODUCT
Metal- and reagent-free highly selective anodic cross-coupling reaction of phenols.
Siegfried R. WaldvogelBernd ElslerKatrin Marie DyballaRobert FrankeRobert FrankeDieter Schollmeyersubject
ElectrolysisFormic acidInorganic chemistryGeneral ChemistryCatalysisCoupling reactionCatalysislaw.inventionchemistry.chemical_compoundchemistryPhenolslawMetalsReagentOxidizing agentOxidative coupling of methaneIndicators and ReagentsMethanolElectrodesdescription
The direct oxidative cross-coupling of phenols is a very challenging transformation, as homo-coupling is usually strongly preferred. Electrochemical methods circumvent the use of oxidizing reagents or metal catalysts and are therefore highly attractive. Employing electrolytes with a high capacity for hydrogen bonding, such as methanol with formic acid or 1,1,1,3,3,3-hexafluoro-2-propanol, a direct electrolysis in an undivided cell provides mixed 2,2′-biphenols with high selectivity. This mild method tolerates a variety of moieties, for example, tert-butyl groups, which are not compatible with other strong electrophilic media but vital for later catalytic applications of the formed products.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-20 | Angewandte Chemie (International ed. in English) |