6533b7d9fe1ef96bd126d723
RESEARCH PRODUCT
Analysis of the human a-wave ERG component
Maria BraiR. BarracoL BellomonteM Anastasisubject
LightPhysiologyBiomedical EngineeringBiophysicsStimulus (physiology)Radiation DosageModels BiologicalLuminanceRetinaNight blindness RetinaPhysiology (medical)ElectroretinographyHumansComputer SimulationPhotoreceptor CellsDiagnosis Computer-AssistedMathematicsDose-Response Relationship Drugbusiness.industryStochastic processPattern recognitionSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Artificial intelligencebusinessAlgorithmsPhotic Stimulationdescription
The a-wave is one of the main issues of research in the field of ocular electrophysiology, since it is strictly connected with early photoreceptoral activities. The present study proposes mathematical methods that analyse this component in human subjects, and supports experimental evidence relating to possible correlations among the responses of photoreceptoral units under a light stimulus. The investigation is organized in two parts: the first part concerns the onset and the initial slope, up to the first minimum (about 10-15 ms), the second part deals with the main portion of the wave, up to about 30 ms. In both cases, the a-waves, recorded at various levels of luminance, have been fitted with a set of appropriate functions representing possible models of physiological behaviour which would take place in the early stages of phototransduction. The statistical nature of the underlying processes is also discussed. The results indicate that correlations occur in the early stages, whereas random processes are set up later.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-07-24 | Physiological Measurement |