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RESEARCH PRODUCT
Conformational Changes and Charge Transfer in Biomolecules Resolved Using Dynamic Enhanced Raman Correlation Spectroscopy
Alexandre BouhelierEric FinotAymeric LerayJean-emmanuel Clémentsubject
Materials scienceStatic ElectricityMolecular ConformationMetal Nanoparticles02 engineering and technologyPéclet numberSpectrum Analysis Raman010402 general chemistry01 natural sciencessymbols.namesakeAdsorptionMaterials ChemistryMoleculePhysical and Theoretical ChemistryDiffusion (business)chemistry.chemical_classificationQuantitative Biology::BiomoleculesBiomoleculeTryptophanTryptophan021001 nanoscience & nanotechnology0104 chemical sciencesSurfaces Coatings and FilmschemistryChemical physicssymbols[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]Gold0210 nano-technologyRaman spectroscopyTwo-dimensional nuclear magnetic resonance spectroscopydescription
International audience; In this contribution, we report that conforma-tional changes of molecules that are often buried in a wide-distributed Gaussian distribution can be discerned by analyzing the dynamics of specific Raman lines. We investigate the pertinence of the auto-and cross-correlation functions applied to the dynamics of three Raman lines of an amino acid, the tryptophan. The cross-correlation between intensity and the Raman band is an indicator of the charge transfer during the diffusion limited reaction of tryptophan and the gold surface. The Pećlet number Pe can provide a valuable indicator of the convective and/or diffusive features of each Raman band. Adsorption induced conformation changes can be identified using the autocorrelation of the multiples states within the Raman band centered at 1550 cm −1 .
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-02-11 | The Journal of Physical Chemistry B |