6533b7d9fe1ef96bd126d7cb

RESEARCH PRODUCT

Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome.

Marcos MeseguerJosé Antonio Martínez-conejeroNicolás GarridoJosé A. HorcajadasJ. JaureguiJosé RemohíCarlos Simón

subject

InfertilityMaleSemenBiologyMale infertilityTranscriptomeAndrologyAntigens NeoplasmSemenmedicineHumansTrypsinRNA MessengerInfertility MaleOligonucleotide Array Sequence Analysisurogenital systemGynecologic pathologyGene Expression ProfilingObstetrics and GynecologyDNAgamma-Glutamyltransferasemedicine.diseaseSpermSpermatozoaGene expression profilingFertilityReproductive MedicineGene chip analysisTrypsinogenApoptosis Regulatory Proteins

description

Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology. Consequently, there is a need for accurate diagnostic tools in this area, and microarray technology emerges as promising. We present, for the first time, preliminary results of a comparison of sperm mRNA expression profiles between fertile and infertile men with normal semen parameters, discovering profound discrepancies between groups, with potential diagnostic and therapeutic possibilities.

yearjournalcountryeditionlanguage
2007-01-29Fertility and sterility
10.1016/j.fertnstert.2008.01.078https://pubmed.ncbi.nlm.nih.gov/18367176