6533b7dafe1ef96bd126d894
RESEARCH PRODUCT
Self-assembly properties of bile acid derivatives of L-cysteine, L-valine and L-serine alkyl esters
Virpi NoponenManu LahtinenArto ValkonenHannu SaloElina Sievänensubject
chemistry.chemical_classificationAqueous solutionBile acidmedicine.drug_classStereochemistryGeneral ChemistryAmino acidchemistryValineX-ray crystallographymedicineOrganic chemistryMoietySelf-assemblyta116Alkyldescription
Comprehensive self-assembly studies for nine bile acid amides of amino acid esters are reported. The number of the hydroxyl groups attached to the steroidal skeleton and the character of the amino acid ester moiety were used as variables when examining the self-assembly properties of the compounds. Two of the compounds were shown to undergo self-assembly leading to organogelation. In addition, preliminary self-assembly studies in aqueous mixtures of polar organic solvents were conducted. Microscopic methods (optical microscopy and scanning electron microscopy) were utilised in order to gain a deeper insight into the self-assembled structures. Furthermore, single-crystal X-ray structures for three of the compounds were solved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-10-23 | Supramolecular Chemistry |