6533b7dafe1ef96bd126d989
RESEARCH PRODUCT
Catalytic asymmetric conjugate addition of terminal alkynes to β-trifluoromethyl α,β-enones.
Amparo Sanz-marcoAndrea Garcia‐ortizGonzalo BlayJosé R. Pedrosubject
TrifluoromethylHydrocarbons FluorinatedMolecular StructureStereochemistryChemistryMetals and AlloysEnantioselective synthesisStereoisomerismGeneral ChemistryKetonesCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCatalysischemistry.chemical_compoundAlkynylationTerminal (electronics)AlkynesMaterials ChemistryCeramics and CompositesEnantiomerConjugatedescription
The first enantioselective conjugate alkynylation of β-trifluoromethyl α,β-enones using terminal alkynes and a taniaphos–Cu(I) complex as catalyst is described. Ketones bearing a trifluoromethylated propargylic chiral centre in the β-position were obtained with good yields and high enantiomeric excesses (up to 99%).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-21 | Chemical communications (Cambridge, England) |