6533b7dafe1ef96bd126e00b
RESEARCH PRODUCT
Unusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor
Timothy J. TricheJose CostaTommie Sue TralkaHans Peter DienesCarole Yeesubject
Pathologymedicine.medical_specialtyChemistryIntranuclear InclusionsTumor cellsmedicine.diseaseFibrilPrimary tumorTumor tissuePathology and Forensic Medicinelaw.inventionTransplantationStructural BiologylawmedicineNon b hepatitisElectron microscopedescription
We describe previously unreported intranuclear inclusions in 2 cases of malignant fibrous histiocytoma. The inclusions were found in 2-10% of the tumor cells removed from the patients and in 2-10% of the cells examined in tumor tissue xenotransplanted in nude mice. By stereo electron microscopy the inclusions are closely packed undulating fibrils 18-23 nm in diameter. They are sometimes associated with fibrillary bodies. They closely resemble the inclusions reported in some animals inoculated with serum from patients with non-A non-B hepatitis; however, their nature at present is unknown.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1982-01-01 | Ultrastructural Pathology |