6533b7dafe1ef96bd126e083

RESEARCH PRODUCT

Evaluation of Oxygen Diffusion Distances in Human Breast Cancer Using Cell Line Specific in Vivo Data: Role of Various Pathogenetic Mechanisms in the Development of Tumor Hypoxia

Peter VaupelF. KallinowskiK. Groebe

subject

Pathologymedicine.medical_specialtyTumor hypoxiaTumor microcirculationCancerBiologyHypoxia (medical)medicine.diseaseIn vivoCell cultureMicrocirculatory Bedmedicinemedicine.symptomFlux (metabolism)

description

Radiobiological hypoxia in malignant tumors has been shown to originate (i) from spatial and temporal functional disturbances of tumor microcirculation resulting in a limited convective O2 flux in microregions even in tissue areas exhibiting high vascular densities, and (ii) from morphological abnormalities of the microcirculatory bed leading to a limitation of the diffusive O2 flux. In addition to these pathogenetic mechanisms, systemic factors (anemia, arterial hypoxia) can also play a role in the development of tumor hypoxia.

yearjournalcountryeditionlanguage
1988-01-01
https://doi.org/10.1007/978-1-4615-9510-6_88