Functional relevance of presynaptic muscarinic autoreceptors.

6533b7dafe1ef96bd126e1ca

RESEARCH PRODUCT

Functional relevance of presynaptic muscarinic autoreceptors.

H. Kilbinger C. Dietrich R. S. Von Bardeleben

subject

medicine.medical_specialty General Neuroscience Guinea Pigs Presynaptic Terminals Muscarinic acetylcholine receptor M3 Muscarinic acetylcholine receptor M2 Muscle Smooth Muscarinic acetylcholine receptor M1 Pharmacology Biology In Vitro Techniques Receptors Muscarinic Trachea Endocrinology Postsynaptic potential Ileum Physiology (medical)Internal medicine Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor M5 medicine Muscarinic acetylcholine receptor M4 Animals Acetylcholine medicine.drug

description

Pre- and postsynaptic muscarinic receptors have been characterized in the isolated trachea and ileal circular muscle of the guinea pig. The muscarinic autoreceptors mediating inhibition of acetylcholine release in the circular muscle belong to the M1 subtype, whereas those inhibiting acetylcholine release in the trachea are M2 or M4 receptors. In both tissues the postsynaptic muscarinic receptors are M3 receptors. Blockade of the autoreceptors by selective M1 and M2/M4 receptor antagonists leads to facilitation of cholinergic neurotransmission.

year	journal	country	edition	language
1993-01-01	Journal of physiology, Paris

10.1016/0928-4257(93)90001-a https://pubmed.ncbi.nlm.nih.gov/8305900

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