6533b7dafe1ef96bd126e204
RESEARCH PRODUCT
Neural generators of the frequency-following response elicited to stimuli of low and high frequency: A magnetoencephalographic (MEG) study.
Jari L. O. KurkelaNatàlia Gorina-caretaCarles EsceraJarmo A. HämäläinenPiia Astikainensubject
magnetoencephalographyInferior colliculusMaleAuditory Pathwaysauditory plasticityFrequency following responses0302 clinical medicineMEGmedicine.diagnostic_test05 social sciencesAuditory plasticityMagnetoencephalographyElectroencephalographyMedial geniculate bodyspeech sound encodingkuulofrequency following responseshavaintopsykologiamedicine.anatomical_structureNeurologyNeural sourcesAuditory PerceptionEvoked Potentials AuditoryFemalePsychologyärsykkeetRC321-571AdultCognitive NeuroscienceThalamusNeurosciences. Biological psychiatry. NeuropsychiatryCognitive neuroscienceAuditory cortexneural sources050105 experimental psychology03 medical and health sciencesYoung AdultmedicineAuditory systemHumans0501 psychology and cognitive sciencesfundamental frequencyFundamental frequencyAuditory CortextaajuusMagnetoencephalographyFrequency following responseSpeech sound encodingAcoustic Stimulationkognitiivinen neurotiedeNeuroscience030217 neurology & neurosurgerydescription
The frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of the periodic sound features in the ascending auditory system. Seminal studies suggested the FFR as a correlate of subcortical sound encoding, yet recent studies aiming to locate its sources challenged this assumption, demonstrating that FFR receives some contribution from the auditory cortex. Based on frequency-specific phase-locking capabilities along the auditory hierarchy, we hypothesized that FFRs to higher frequencies would receive less cortical contribution than those to lower frequencies, hence supporting a major subcortical involvement for these high frequency sounds. Here, we used a magnetoencephalographic (MEG) approach to trace the neural sources of the FFR elicited in healthy adults (N=19) to low (89 Hz) and high (333 Hz) frequency sounds. FFRs elicited to the high and low frequency sounds were clearly observable on MEG and comparable to those obtained in simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, and cortical contributions to FFR, arranged in frequency-specific configurations. Our results showed that the main contribution to the high-frequency sound FFR originated in the inferior colliculus and the medial geniculate body of the thalamus, with no significant cortical contribution. In contrast, the low-frequency sound FFR had a major contribution located in the auditory cortices, and also received contributions originating in the midbrain and thalamic structures. These findings support the multiple generator hypothesis of the FFR and are relevant for our understanding of the neural encoding of sounds along the auditory hierarchy, suggesting a hierarchical organization of periodicity encoding. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-05-01 | NeuroImage |