6533b7dafe1ef96bd126e212
RESEARCH PRODUCT
Enantioselective zinc-mediated conjugate addition of terminal alkynes to enones.
Gonzalo BlayAmparo Sanz-marcoLuz CardonaJosé R. Pedrosubject
Organic ChemistryEnantioselective synthesischemistry.chemical_elementGeneral ChemistryZincDiethylzincCombinatorial chemistryCatalysislaw.inventionCatalysischemistry.chemical_compoundchemistrylawYield (chemistry)EnantiomerCrystallizationConjugatedescription
Zinc for conjugate alkynylation: The enantioselective conjugate addition of terminal alkynes to 2-arylidene-1,3-diketones in the presence of diethylzinc and a catalytic amount of (R)-VANOL has been developed. The reaction can be applied to different aromatic and heteroaromatic alkynes and enones, giving the expected products in good yield and with enantiomeric excesses up to 91%. The products can be enantiomerically enriched up to 99% ee by crystallization (see scheme).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-08-31 | Chemistry (Weinheim an der Bergstrasse, Germany) |