6533b7dafe1ef96bd126e284

RESEARCH PRODUCT

Opposite effects of beta-adrenoceptor stimulation and 8-bromo-cyclic AMP on potassium efflux in mammalian heart muscle.

I. BleiH. NawrathR. Gegner

subject

Inotropemedicine.medical_specialtyAdrenergic receptorPotassiumGuinea Pigschemistry.chemical_elementAction PotentialsStimulationIn Vitro TechniquesCellular and Molecular Neuroscience8-Bromo Cyclic AMPInternal medicineIsoprenalineReceptors Adrenergic betamedicineCyclic AMPAnimalsMolecular BiologyPharmacologyChemistryMyocardiumIsoproterenolHeartCell BiologyMyocardial ContractionMammalian heartStimulation ChemicalReceptors AdrenergicEndocrinologycardiovascular systemPotassiumMolecular MedicineEffluxmedicine.drug

description

beta-adrenoceptor stimulation by isoprenaline increases the potassium efflux in beating guinea-pig atria. This effect is not mimicked by 8-bromo-cyclic AMP, a cyclic AMP analogue which exerts a positive inotropic effect in this preparation.

yearjournalcountryeditionlanguage
1980-01-15Experientia
10.1007/bf02003981https://pubmed.ncbi.nlm.nih.gov/6244175