6533b7dafe1ef96bd126e2e8

RESEARCH PRODUCT

Ligneous Cervicitis in a Woman With Plasminogen Deficiency Associated With an Atypical Form of Microglandular Hyperplasia

J. CaselitzGuido Von CottaS YounesAndrea UllrichCarsten DenkertSergio FranginiManfred DietelEliane T TaubeVito ChianteraGuiseppe Filiberto VercellinoStephan Pahl

subject

Uterine Cervical NeoplasmPathologymedicine.medical_specialty2734Uterine Cervical NeoplasmsCervicitisAdenocarcinomaDiagnostic ErrorEndometriumPathology and Forensic MedicineYoung AdultMicroglandular hyperplasiaBiomarkers TumorHumansMedicineDiagnostic ErrorsClear-cell adenocarcinomaCervixbusiness.industrySkin Diseases GeneticObstetrics and GynecologyConjunctivitiPlasminogenPlaminogen deficiencyConjunctivitisLigneous cervicitimedicine.diseaseMicroglandular hyperplasiaImmunohistochemistryUterine Cervicitismedicine.anatomical_structureImmunohistochemistryAdenocarcinomaFemalebusinessClear cellAdenocarcinoma Clear CellHumanUterine Cerviciti

description

A 19-yr-old woman with previously diagnosed clear cell adenocarcinoma was referred to the Charité for further treatment. Biopsies were taken from the cervix, the endometrium, pseudomembranes in the peritoneum, and sentinel lymph nodes. The morphologic picture of pseudomembranes and inflammation together with the provided information about plasminogen deficiency of the patients led to the hypothesis of ligneous cervicitis. The previously taken biopsies of the adenocarcinoma were reevaluated and showed a clear cell lesion. Further immunohistochemical examination with antibodies against p16, Ki67, CEA, and p53 could not prove its malignant character. As a result we diagnosed an atypical form of microglandular hyperplasia in a patient with ligneous cervicitis. Ligneous cervicitis is a rare inflammatory condition that might affect all mucus membranes in patients with plasminogen deficiency. This case shows the importance of correlating pathologic and clinical findings in the diagnosis of ligneous cervicitis because of the rarity of the disease and the heterogeneity at presentation. © 2013 International Society of Gynecological Pathologists.

yearjournalcountryeditionlanguage
2013-03-23International Journal of Gynecological Pathology
https://doi.org/10.1097/pgp.0b013e3182625fec