6533b7dafe1ef96bd126e2f5

RESEARCH PRODUCT

Methionine transsulfuration pathway is upregulated in long-lived humans.

Joaquim SolConsuelo BorrásJose Daniel Galo-liconaReinald PamplonaMariona JovéJosep PuigJose ViñaRebeca BerdúnIrene PradasÈLia ObisNatalia Mota-martorellRosanna Cabré

subject

0301 basic medicinemedia_common.quotation_subjectLongevityTranssulfuration pathwayBiologyBiochemistry03 medical and health scienceschemistry.chemical_compound0302 clinical medicineMethionineDownregulation and upregulationTandem Mass SpectrometryPhysiology (medical)Humansmedia_commonchemistry.chemical_classificationAged 80 and overMethionineLongevityMetabolismPhenotypeAmino acid030104 developmental biologyBiochemistrychemistryMetabolome030217 neurology & neurosurgeryHomeostasisChromatography Liquid

description

Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma methionine metabolic profile was determined using a LC-MS/MS platform to systematically define specific phenotypic patterns associated with genotypes of human extreme longevity (centenarians). Our findings demonstrate the presence of a specific plasma profile associated with human longevity characterized by an enhanced transsulfuration pathway and tricarboxylic acid (TCA) cycle intermediates, as well as a reduced content of specific amino acids. Furthermore, our work reveals that centenarians maintain a strongly correlated methionine metabolism, suggesting an improved network integrity, homeostasis and more tightly regulated metabolism. We have discovered a particular methionine signature related to the condition of extreme longevity, allowing the identification of potential mechanisms and biomarkers of healthy aging.

yearjournalcountryeditionlanguage
2020-09-03Free radical biologymedicine
10.1016/j.freeradbiomed.2020.11.026https://pubmed.ncbi.nlm.nih.gov/33271279