6533b7dafe1ef96bd126e2f7
RESEARCH PRODUCT
SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells
L. SantiL. SantiHans-peter RichterHans-peter RichterG. AllavenaG. AllavenaAdriana AlbiniAdriana AlbiniS. ParodiS. ParodiB. F. PontzB. F. Pontzsubject
virusesSimian virus 40BiologyVirus*Cell Transformation Viral Cells Cultured Chemotaxis/*drug effects Embryo Fibroblasts/physiology Fibronectins/*pharmacology Human Peptide Fragments/pharmacology Polyomavirus macacae/*physiologyCellular and Molecular NeurosciencemedicineHumansFibroblastMolecular BiologyCells CulturedPharmacologychemistry.chemical_classificationChemotaxisChemotaxisEmbryoCell BiologyFibroblastsCell Transformation ViralEmbryo MammalianVirologyPeptide FragmentsCell biologyFibronectinsSv40 virusFibronectinmedicine.anatomical_structurechemistryCell culturebiology.proteinMolecular MedicineGlycoproteindescription
SV40-virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-12-15 |