6533b7dafe1ef96bd126e9e3

RESEARCH PRODUCT

Evaluation of Hemodynamic Parameters for Adaptive Control of the Artificial Heart by Simulation of the Vascular System

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Abstract A nonlinear dynamic mathematical model of the cardiovascular system is outlined, which is employable to analyse the hemodynamic system behaviour under normal as well as under pathological conditions. By modifying this model, assuming that cardiac output is constant at a preset level (which is in accordance with most of the total artificial heart systems, since their pumps output is preselected with fixed driving parameters), the hemodynamic behaviour of a circulation system with an artificial heart was simulated. Comparing the simulation results with those obtained from total artificial heart experiments, a good agreement in right atrial and aortic pressure under exercise conditions could be proven. Furthermore, the modified and tested cardiovascular system model can be used as a tool for evaluation of optimal control parameters under given conditions, by quantitatively analysing the artificial heart connected with the vascular system.