6533b7dafe1ef96bd126ea94

RESEARCH PRODUCT

Out for a Walk Along the Secretory Pathway During Programmed Cell Death

subject

description

This chapter provides a comprehensive updated analysis on the role of the secretory pathway in the orchestration of cell’s demise, an emerging and promising research topic in the field of plant programmed cell death (PCD). Since my first review on this topic, a plethora of data has been published supporting the concept that endomembrane system-forming subcellular compartments cooperate to coordinate cellular responses to developmental and environmental cues and thereby can dictate a cell’s ultimate fate. Thus, the early secretory pathway, encompassing the endoplasmic reticulum and Golgi apparatus, can be involved in the perception of extrinsic and intrinsic stimuli. It can also be an active player in cell death regulations and can invoke other organelles (such as the mitochondrion and autophagosomal compartment) under specific conditions. Furthermore, the vacuole and autophagosomal compartment, together or independently, can then act as cell death executioners and can dismantle cellular structures.