6533b7dafe1ef96bd126eb98
RESEARCH PRODUCT
Catalytic Enantioselective Addition of Me2Zn to Isatins
Carlos VilaGonzalo BlayAndrés Del CampoJosé R. Pedrosubject
Dimethylzincchemistry.chemical_elementZinc010402 general chemistrylcsh:Chemical technology01 natural sciencesisatinCatalysisCatalysislcsh:Chemistrychemistry.chemical_compoundchiral α-hydroxyamide3-hydroxyoxindoleCatàlisilcsh:TP1-1185Physical and Theoretical Chemistry010405 organic chemistryChemistryIsatinzincEnantioselective synthesisasymmetric catalysisCombinatorial chemistry0104 chemical scienceslcsh:QD1-999mandelamidesQuímica orgànicadescription
Chiral α-hydroxyamide L5 derived from (S)-(+)-mandelic acid catalyzes the enantioselective addition of dimethylzinc to isatins affording the corresponding chiral 3-hydroxy-3-methyl-2-oxindoles with good yields and er up to 90:10. Furthermore, several chemical transformations were performed with the 3-hydroxy-2-oxindoles obtained.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |