6533b7dafe1ef96bd126eb9c
RESEARCH PRODUCT
Collagen biology and non‐invasive biomarkers of liver fibrosis
Rose C. ChristianMette Juul NielsenDaniel Guldager Kring RasmussenCecilie L. BagerDiana Julie LeemingJacob GeorgeNatasja Stæhr GudmannRambabu SurabattulaYi LuoIda VillesenMorten A. KarsdalSigne Holm NielsenSamuel Joseph DanielsRohit LoombaDiane E. ShevellDetlef SchuppanDetlef Schuppansubject
Liver CirrhosisLiver injuryCirrhosisHepatologyFatty liverDiseaseBiologyBioinformaticsmedicine.diseaseChronic liver disease03 medical and health sciences0302 clinical medicineLiverNon-alcoholic Fatty Liver DiseaseFibrosis030220 oncology & carcinogenesismedicineHumansBiomarker (medicine)030211 gastroenterology & hepatologyCollagenBiologyBiomarkersTissue homeostasisdescription
There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-04-01 | Liver International |