6533b7dafe1ef96bd126ebd3
RESEARCH PRODUCT
Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question.
Warren StroberMarkus F. NeurathIvan J. FussMonica BoirivantSusetta FinottoPeter R. Gallesubject
T-LymphocytesImmunologyApoptosisInflammatory bowel diseaseImmunology and AllergyMedicineEffective treatmentAnimalsHumansColitisIntestinal MucosaReceptorImmunity MucosalT-cell apoptosisbiologyCell Deathbusiness.industryInflammatory Bowel Diseasesmedicine.diseaseInflammatory Bowel Diseasesdigestive system diseasesApoptosisImmunologybiology.proteinAntibodybusinessdescription
T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-04-05 | Trends in immunology |