6533b7dafe1ef96bd126ec3c
RESEARCH PRODUCT
Thrombin-antithrombin III complexes in type II diabetes mellitus.
Salvatore AmatoAlberto NotarbartoloGiovanni DavìFrancesco GennaroI. CatalanoMaurizio AvernaAntonio SpatolaGiuseppe Montaltosubject
AdultMalemedicine.medical_specialtySpecific detectionEndocrinology Diabetes and MetabolismAntithrombin IIIType ii diabetesEndocrinologyReference ValuesDiabetes mellitusInternal medicineInternal MedicinemedicineHumansAgedAged 80 and overHeterogeneous groupVascular diseasebusiness.industryThrombin/Antithrombin IIIAge FactorsThrombinMiddle Agedmedicine.diseaseCerebrovascular DisordersCoagulative necrosisEndocrinologyDiabetes Mellitus Type 2Thrombin activityRegression AnalysisFemalebusinessDiabetic Angiopathiesdescription
Several studies suggest that diabetes is associated with a hypercoagulable state. Therefore determination of thrombin-antithrombin complex (TAT) could represent a sensitive parameter for specific detection of a latent activation of the clotting system. The present study documents increased plasma TAT in a heterogeneous group of non-insulin-dependent diabetic patients. The finding of increased TAT levels both in diabetic patients with vascular complications and in vascular disease patients without diabetes suggests a relationship between existing vascular disease and the hemostatic mechanism that produces augmented thrombin activity. In acute vascular occlusions the presence of diabetes seems to increase activation of the coagulative system.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | Journal of diabetes and its complications |