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RESEARCH PRODUCT
Controlling the Stealth Effect of Nanocarriers through Understanding the Protein Corona
Katharina LandfesterSusanne SchöttlerSusanne SchöttlerVolker MailänderVolker Mailändersubject
Drug CarriersBiodistributionChemistryPolymeric nanocarriersNanotechnologyProtein Corona02 engineering and technologyGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesCatalysis0104 chemical sciencesDrug Delivery SystemsDrug deliveryHumansNanoparticlesProtein CoronaNanocarriers0210 nano-technologydescription
The past decade has seen a significant increase in interest in the use of polymeric nanocarriers in medical applications. In particular, when used as drug vectors in targeted delivery, nanocarriers could overcome many obstacles for drug therapy. Nevertheless, their application is still impeded by the complex composition of the blood proteins covering the particle surface, termed the protein corona. The protein corona complicates any prediction of cell interactions, biodistribution, and toxicity. In particular, the unspecific uptake of nanocarriers is a major obstacle in clinical studies. This Minireview provides an overview of what we currently know about the characteristics of the protein corona of nanocarriers, with a focus on surface functionalization that reduces unspecific uptake (the stealth effect). The ongoing improvement of nanocarriers to allow them to meet all the requirements necessary for successful application, including targeted delivery and stealth, are further discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-03-03 | Angewandte Chemie International Edition |