A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.)

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RESEARCH PRODUCT

A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.)

Maurilio Ponzoni Fabio Facchetti Claudio Tripodo Maria Raffaella Ambrosio Alberto Zamo Stefano Lazzi Arianna Di Napoli Domenico Novero Marco Lucioni Marco Paulli Claudio Agostinelli Elena Sabattini Alessia Carbone Stefano Ascani Stefano Pileri Luigi Ruco Lorenzo Leoncini D. Remotti

subject

0301 basic medicine medicine.medical_specialty Matching (statistics)Lymphoma B-Cell Lymphoma double hit Computer science MYC Double hit Fluorescence Pathology and Forensic Medicine Immunophenotyping 03 medical and health sciences 0302 clinical medicine FISH Diagnosis medicine Practical algorithm Humans Intensive care medicine B-cell lymphoma Molecular Biology In Situ Hybridization In Situ Hybridization Fluorescence HGBL Brief Report B-Cell Treatment options Correction Diagnosis; DLBCL; Double hit; FISH; HGBL; MYC; Humans; Immunophenotyping; In Situ Hybridization Fluorescence; Lymphoma B-Cell; Algorithms Cell Biology General Medicine Diagnosis DLBCL Double hit FISH HGBL MYC medicine.disease Diagnosis; DLBCL; double hit; FISH; HGBL; MYC Optimal management Molecular analysis 030104 developmental biology 030220 oncology & carcinogenesis DLBCL Position paper Proper treatment Algorithms Diagnosi Human

description

An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.

year	journal	country	edition	language
2019-01-01

10.1007/s00428-019-02637-2 http://hdl.handle.net/11573/1310046