6533b7dafe1ef96bd126ed9b
RESEARCH PRODUCT
Characterization of cells involved in the formation of granuloma. An ultrastructural study on macrophages, epitheloid cells, and giant cells in experimental tubulo-interstitial nephritis.
W. ThoenesK. H. Langersubject
Basement membraneMaleCell fusionGranulomaInterstitial nephritisMacrophagesLanghans giant cellGeneral MedicineBiologymedicine.diseaseBasement MembraneMonocytesCell biologyRatsCell FusionMicroscopy Electronmedicine.anatomical_structureKidney TubulesGiant cellGranulomamedicineUltrastructureAnimalsNephritis InterstitialNephritisdescription
In experimental tubulo-interstitial (anti-basement membrane) nephritis of the rat, granulomatous inflammation develops around immunologically altered tubular basement membranes. The present light- and electron microscopic studies indicate that in the course of the granulomatous reaction, tissue monocytes evolve from blood monocytes and pursue two independent pathways of differentation. On the one hand they may differentiate into macrophages ("distant from tubules") or, alternatively, into epitheloid cells ("adjacent to tubules"). The latter, through cell fusion, develop into multinucleated giant cells of the Langhans' type. The cytoplasmic components of the epitheloid cells and the multinucleated giant cells should be interpreted as an activation of cellular biosynthesis. Its products, upon being secreted at the immunodefective basement membrane, will obviously serve immune defense mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1981-12-01 | Virchows Archiv. B, Cell pathology including molecular pathology |