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RESEARCH PRODUCT
Ultrastructural Pathology of Anaplastic and Grade II Ependymomas reveals Distinctive Ciliary Structures - Electron Microscopy Redux
Jerónimo Forteza-vilaRosa M. Reyes SantíasRafael CanoMario Soriano-navarroMónica RamírezLaia BernetMarcos Arturo Martínez BanaclochaJosé Manuel García-verdugoClara Alfaro-cervellosubject
EpendymomaMalePathologymedicine.medical_specialtyEpendymal CellependymomaCentrioleVentricular systemBiologyUltrastructural PathologyPathology and Forensic MedicineYoung AdultMicroscopy Electron TransmissionStructural BiologymedicineBasal bodyHumansCiliaChildelectron microscopyBrain NeoplasmsCiliumciliaAnatomyMiddle Agedmedicine.diseaseEpendymomaUltrastructureAnaplastic ependymomaFemaleNeoplasm Gradingprimary ciliumdescription
Ependymoma tumors likely derive from the ependymal cells lining the CNS ventricular system. In grade II ependymomas, tumor cells resemble typical ependymocytes, while anaplastic ependymomas are poorly differentiated. We studied three grade II and one anaplastic ependymoma, focusing on the ciliary structures. To unambiguously characterize the ultrastructure and number of cilia, we performed electron microscopy serial section analysis of individual cells. Differentiated ependymomas contained large basal bodies and up to three cilia, and lacked centrioles. Anaplastic ependymoma cells showed instead two perpendicularly oriented centrioles and lacked cilia or basal bodies. These findings could contribute to understand the mechanisms of ependymoma aggressiveness.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |