Pharmacological evaluation of the dichloromethanol extract fromInula crithmoides L.

6533b7dafe1ef96bd126f3dd

RESEARCH PRODUCT

Pharmacological evaluation of the dichloromethanol extract fromInula crithmoides L.

E. Primo Yúfera Juan V. Esplugues M D Barrachina I. Sanz R. Bello

subject

Pharmacology Inula biology Analgesic Biological activity Pharmacology biology.organism_classification Acute toxicity chemistry.chemical_compound chemistry In vivo Anesthesia Toxicity medicine Histamine Acetylcholine medicine.drug

description

The pharmacological effect of the dichloromethanol extract of Inula crithmoides L. was analysed in in vitro and in vivo models. The extract dose-dependently decreased arterial blood pressure and furthermore it showed low acute toxicity, CNS depressor activity and analgesic and antiinflammatory effects. Preincubation of the guinea-pig ileum and rat duodenum (100 μg/mL) produced a significant reduction in the contractile effects of histamine and acetylcholine and a concentration-related inhibition of the effects of serotonin. Following further fractionation the methylene chloride/acetone (50/50) fraction caused a significant decrease in motor activity and significantly reduced the threshold of pain chemical stimulus.

year	journal	country	edition	language
1995-06-01	Phytotherapy Research

https://doi.org/10.1002/ptr.2650090412

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