6533b7dafe1ef96bd126f458
RESEARCH PRODUCT
Cell cycle: Aetiology of age-associated aneuploidy: a mechanism based on the 'free radical theory of ageing'
Juan J. Tarínsubject
GeneticsSenescenceMechanism (biology)RehabilitationObstetrics and GynecologyMechanism basedAneuploidyGerminal cellBiologymedicine.diseaseBioinformaticsmedicine.disease_causeReproductive MedicineAgeingmedicineOxidative stressFree-radical theory of agingdescription
A general model is put forward to explain the mechanism by which age-associated aneuploidies are produced. This is based on the free radical theory of ageing, which assumes a rise in oxidative stress with age. It is proposed that determination of indicators of oxidative stress in oocytes from various sources could be a first step in the testing of this hypothesis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-06-01 | Human Reproduction |