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RESEARCH PRODUCT
G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson's Disease?
Chao RenChao RenChao RenYu DingYu DingShizhuang WeiLina GuanCaiyi ZhangYongqiang JiFen WangShaohua YinPeiyuan Yinsubject
Parkinson's diseaseNatural agingDiseaseReviewBioinformatics050105 experimental psychologylcsh:RC321-57103 medical and health sciencesBehavioral Neuroscience0302 clinical medicineG2019s mutationG2019S mutationmedicine0501 psychology and cognitive scienceslcsh:Neurosciences. Biological psychiatry. NeuropsychiatryBiological Psychiatrybusiness.industrydisease modelpathogenesis05 social sciencesLRRK2medicine.diseaseLRRK2nervous system diseasesPsychiatry and Mental healthNeuropsychology and Physiological PsychologyMultiple factorsVariation (linguistics)NeurologyEtiologyParkinson’s diseasebusiness030217 neurology & neurosurgeryNeurosciencedescription
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have found that PD patients with the LRRK2:G2019S variation have the typical clinical manifestations of PD, which may be familial or sporadic, and have age-dependent pathogenic characteristics. Therefore, the LRRK2:G2019S variation may be an ideal model to study the interaction of multiple factors such as genetic, environmental and natural aging factors in PD in the future. This article reviewed the progress of LRRK2:G2019S studies in PD research in order to provide new research ideas and directions for the pathogenesis and treatment of PD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-04-15 | Frontiers in human neuroscience |