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RESEARCH PRODUCT
Nonlinear effects of respiration on the crosstalk between cardiovascular and cerebrovascular control systems.
Gianluca RossatoBeatrice De MariaAlberto PortaAndrea MarchiVlasta BaripGiandomenico NolloLuca Faessubject
Mean arterial pressuremedicine.medical_specialtySupine positionGeneral Mathematics0206 medical engineeringGeneral Physics and Astronomy02 engineering and technology030204 cardiovascular system & hematologyBaroreflexCerebral autoregulationCardiovascular System03 medical and health sciencesPhysics and Astronomy (all)0302 clinical medicineEngineering (all)Conditional joint symbolic analysiInternal medicineRespirationmedicineHeart rate variabilityAutonomic nervous system; Baroreflex; Cerebral autoregulation; Conditional joint symbolic analysis; Head-up tilt; Heart rate variability; Mathematics (all); Physics and Astronomy (all); Engineering (all)Autonomic nervous systemMathematics (all)Heart rate variabilitybusiness.industryAutonomic nervous system; Baroreflex; Cerebral autoregulation; Conditional joint symbolic analysis; Head-up tilt; Heart rate variability; Mathematics (all); Engineering (all); Physics and Astronomy (all)Head-up tiltGeneral EngineeringBaroreflex020601 biomedical engineeringCerebral autoregulationAutonomic nervous systemCerebral blood flowConditional joint symbolic analysisSettore ING-INF/06 - Bioingegneria Elettronica E InformaticaCardiologybusinessdescription
Cardiovascular and cerebrovascular regulatory systems are vital control mechanisms responsible for guaranteeing homeostasis and are affected by respiration. This work proposes the investigation of cardiovascular and cerebrovascular control systems and the nonlinear influences of respiration on both regulations through joint symbolic analysis (JSA), conditioned or unconditioned on respiration. Interactions between cardiovascular and cerebrovascular regulatory systems were evaluated as well by performing correlation analysis between JSA indexes describing the two control systems. Heart period, systolic and mean arterial pressure, mean cerebral blood flow velocity and respiration were acquired on a beat-to-beat basis in 13 subjects experiencing recurrent syncope episodes (SYNC) and 13 healthy individuals (non-SYNC) in supine resting condition and during head-up tilt test at 60° (TILT). Results showed that JSA distinguished conditions and groups, whereas time domain parameters detected only the effect of TILT. Respiration affected cardiovascular and cerebrovascular regulatory systems in a nonlinear way and was able to modulate the interactions between the two control systems with different outcome in non-SYNC and SYNC groups, thus suggesting that the analysis of the impact of respiration on cardiovascular and cerebrovascular regulatory systems might improve our understanding of the mechanisms underpinning the development of postural-related syncope.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Philosophical transactions. Series A, Mathematical, physical, and engineering sciences |