Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry

6533b7dafe1ef96bd126f672

RESEARCH PRODUCT

Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry

Cyril Zakine Rodrigue Garcia Kumar Narayanan Estelle Gandjbakhch Vincent Algalarrondo Nicolas Lellouche Marie-cécile Perier Laurent Fauchier Daniel Gras Pierre Bordachar Olivier Piot Dominique Babuty Nicolas Sadoul Pascal Defaye Jean-claude Deharo Didier Klug Christophe Leclercq Fabrice Extramiana Serge Boveda Eloi Marijon Philippe Maury Christine Alonso Frederic Anselme Jean-sylvain Hermida Gabriel Laurent Jacques Mansourati Frederic Sacher Jérôme Taieb Giuseppe Boriani Marco Proietti Cécile Laroche Francisco Marín Michael Nabauer Tatjana Potpara Gheorghe-andrei Dan Zbigniew Kalarus Luigi Tavazzi Aldo Maggioni Gregory Lip G-a Dan A Goda G Mairesse T Shalganov L Antoniades M Taborsky S Riahi P Muda I García Bolao K Etsadashvili E Simantirakis M Haim A Azhari J Najafian M Santini E Mirrakhimov K A Kulzida A Erglis L Poposka M Burg H Crijns Ö Erküner D Atar R Lenarczyk M Martins Oliveira D Shah E Serdechnaya E Diker D Lane E Zëra U Ekmekçiu V Paparisto M Tase H Gjergo J Dragoti M Ciutea N Ahadi Z El Husseini M Raepers J Leroy P Haushan A Jourdan C Lepiece L Desteghe J Vijgen P Koopman G Van Genechten H Heidbuchel T Boussy M De Coninck H Van Eeckhoutte N Bouckaert A Friart J Boreux C Arend P Evrard L Stefan E Hoffer J Herzet M Massoz C Celentano M Sprynger L Pierard P Melon B Van Hauwaert C Kuppens D Faes D Van Lier A Van Dorpe A Gerardy O Deceuninck O Xhaet F Dormal E Ballant D Blommaert D Yakova M Hristov T Yncheva N Stancheva S Tisheva M Tokmakova F Nikolov D Gencheva B Kunev M Stoyanov D Marchov V Gelev V Traykov A Kisheva H Tsvyatkov R Shtereva S Bakalska-georgieva S Slavcheva Y Yotov M Kubíčková A Marni Joensen A Gammelmark L Hvilsted Rasmussen P Dinesen S Krogh Venø B Sorensen A Korsgaard K Andersen C Fragtrup Hellum A Svenningsen O Nyvad P Wiggers O May A Aarup B Graversen L Jensen M Andersen M Svejgaard S Vester S Hansen V Lynggaard M Ciudad R Vettus A Maestre S Castaño S Cheggour J Poulard V Mouquet S Leparrée J Bouet A Doucy H Duquenne A Furber J Dupuis J Rautureau M Font P Damiano M Lacrimini J Abalea S Boismal T Menez G Range H Gorka C Laure C Vassalière N Elbaz K Djouadi F Roubille D Dietz J Davy M Granier P Winum C Leperchois-jacquey H Kassim J Le Heuzey J Fedida C Maupain C Himbert F Hidden-lucet G Duthoit N Badenco T Chastre X Waintraub M Oudihat J Lacoste C Stephan H Bader N Delarche L Giry D Arnaud C Lopez F Boury I Brunello M Lefèvre R Mingam M Haissaguerre M Le Bidan D Pavin V Le Moal T Beitar I Martel A Schmid N Sadki C Romeyer-bouchard A Da Costa I Arnault M Boyer C Piat N Lozance S Nastevska A Doneva B Fortomaroska Milevska B Sheshoski K Petroska N Taneska N Bakrecheski K Lazarovska S Jovevska V Ristovski A Antovski E Lazarova I Kotlar J Taleski S Kedev N Zlatanovik S Jordanova T Bajraktarova Proseva S Doncovska D Maisuradze A Esakia E Sagirashvili K Lartsuliani N Natelashvili N Gumberidze R Gvenetadze N Gotonelia N Kuridze G Papiashvili I Menabde S Glöggler A Napp C Lebherz H Romero K Schmitz M Berger M Zink S Köster J Sachse E Vonderhagen G Soiron K Mischke R Reith M Schneider W Rieker D Boscher A Taschareck A Beer D Oster O Ritter J Adamczewski S Walter A Frommhold E Luckner J Richter M Schellner S Landgraf S Bartholome R Naumann J Schoeler D Westermeier F William K Wilhelm M Maerkl R Oekinghaus M Denart M Kriete U Tebbe T Scheibner M Gruber A Gerlach C Beckendorf L Anneken M Arnold S Lengerer Z Bal C Uecker H Förtsch S Fechner V Mages E Martens H Methe T Schmidt B Schaeffer B Hoffmann J Moser K Heitmann S Willems C Klaus I Lange M Durak E Esen F Mibach H Mibach A Utech M Gabelmann R Stumm V Ländle C Gartner C Goerg N Kaul S Messer D Burkhardt C Sander R Orthen S Kaes A Baumer F Dodos A Barth G Schaeffer J Gaertner J Winkler A Fahrig J Aring I Wenzel S Steiner A Kliesch E Kratz K Winter P Schneider A Haag I Mutscher R Bosch J Taggeselle S Meixner A Schnabel A Shamalla H Hötz A Korinth C Rheinert G Mehltretter B Schön N Schön A Starflinger E Englmann G Baytok T Laschinger G Ritscher A Gerth D Dechering L Eckardt M Kuhlmann N Proskynitopoulos J Brunn K Foth C Axthelm H Hohensee K Eberhard S Turbanisch N Hassler A Koestler G Stenzel D Kschiwan M Schwefer S Neiner S Hettwer M Haeussler-schuchardt R Degenhardt S Sennhenn M Brendel A Stoehr W Widjaja S Loehndorf A Logemann J Hoskamp J Grundt M Block R Ulrych A Reithmeier V Panagopoulos C Martignani D Bernucci E Fantecchi I Diemberger M Ziacchi M Biffi P Cimaglia J Frisoni I Giannini S Boni S Fumagalli S Pupo A Di Chiara P Mirone F Pesce C Zoccali V Malavasi A Mussagaliyeva B Ahyt Z Salihova K Koshum-bayeva A Kerimkulova A Bairamukova B Lurina R Zuzans S Jegere I Mintale K Kupics K Jubele O Kalejs K Vanhear M Cachia E Abela S Warwicker T Tabone R Xuereb D Asanovic D Drakalovic M Vukmirovic N Pavlovic L Music N Bulatovic A Boskovic H Uiterwaal N Bijsterveld J De Groot J Neefs N Van Den Berg F Piersma A Wilde V Hagens J Van Es J Van Opstal B Van Rennes H Verheij W Breukers G Tjeerdsma R Nijmeijer D Wegink R Binnema S Said S Philippens W Van Doorn T Szili-torok R Bhagwandien P Janse A Muskens M Van Eck R Gevers N Van Der Ven A Duygun B Rahel J Meeder A Vold C Holst Hansen I Engset B Dyduch-fejklowicz E Koba M Cichocka A Sokal A Kubicius E Pruchniewicz A Kowalik-sztylc W Czapla I Mróz M Kozlowski T Pawlowski M Tendera A Winiarska-filipek A Fidyk A Slowikowski M Haberka M Lachor-broda M Biedron Z Gasior M Kołodziej M Janion I Gorczyca-michta B Wozakowska-kaplon M Stasiak P Jakubowski T Ciurus J Drozdz M Simiera P Zajac T Wcislo P Zycinski J Kasprzak A Olejnik E Harc-dyl J Miarka M Pasieka M Ziemińska-łuć W Bujak A ŚLiwiński A Grech J Morka K Petrykowska M Prasał G Hordyński P Feusette P Lipski A Wester W Streb J Romanek P Woźniak M Chlebuś P Szafarz W Stanik M Zakrzewski J Kaźmierczak A Przybylska E Skorek H Błaszczyk M Stępień S Szabowski W Krysiak M Szymańska J Karasiński J Blicharz M Skura K Hałas L Michalczyk Z Orski K Krzyżanowski A Skrobowski L Zieliński M Tomaszewska-kiecana M Dłużniewski M Kiliszek M Peller M Budnik P Balsam G Opolski A Tymińska K Ozierański A Wancerz A Borowiec E Majos R Dabrowski H Szwed A Musialik-lydka A Leopold-jadczyk E Jedrzejczyk-patej M Koziel M Mazurek K Krzemien-wolska P Starosta E Nowalany-kozielska A Orzechowska M Szpot M Staszel S Almeida H Pereira L Brandão Alves R Miranda L Ribeiro F Costa F Morgado P Carmo P Galvao Santos R Bernardo P Adragão G Ferreira Da Silva M Peres M Alves M Leal A Cordeiro P Magalhães P Fontes S Leão A Delgado A Costa B Marmelo B Rodrigues D Moreira J Santos L Santos A Terchet D Darabantiu S Mercea V Turcin Halka A Pop Moldovan A Gabor B Doka G Catanescu H Rus L Oboroceanu E Bobescu R Popescu A Dan A Buzea I Daha I Neuhoff M Baluta R Ploesteanu N Dumitrache M Vintila A Daraban C Japie E Badila H Tewelde M Hostiuc S Frunza E Tintea D Bartos A Ciobanu I Popescu N Toma C Gherghinescu D Cretu N Patrascu C Stoicescu C Udroiu G Bicescu V Vintila D Vinereanu M Cinteza R Rimbas M Grecu A Cozma F Boros M Ille O Tica R Tor A Corina A Jeewooth B Maria C Georgiana C Natalia D Alin D Dinu-andrei M Livia R Daniela R Larisa S Umaar T Tamara M Ioachim Popescu D Nistor I Sus O Coborosanu N Alina-ramona R Dan L Petrescu G Ionescu C Vacarescu E Goanta M Mangea A Ionac C Mornos D Cozma S Pescariu E Solodovnicova I Soldatova J Shutova L Tjuleneva T Zubova V Uskov D Obukhov G Rusanova N Isakova S Odinsova T Arhipova E Kazakevich O Zavyalova T Novikova I Riabaia S Zhigalov E Drozdova I Luchkina Y Monogarova D Hegya L Rodionova V Nevzorova O Lusanova A Arandjelovic D Toncev L Vukmirovic M Radisavljevic M Milanov N Sekularac M Zdravkovic S Hinic S Dimkovic T Acimovic J Saric S Radovanovic A Kocijancic B Obrenovic-kircanski D Kalimanovska Ostric D Simic I Jovanovic I Petrovic M Polovina M Vukicevic M Tomasevic N Mujovic N Radivojevic O Petrovic S Aleksandric V Kovacevic Z Mijatovic B Ivanovic M Tesic A Ristic B Vujisic-tesic M Nedeljkovic A Karadzic A Uscumlic M Prodanovic M Zlatar M Asanin B Bisenic V Vasic Z Popovic D Djikic M Sipic V Peric B Dejanovic N Milosevic S Backovic A Stevanovic A Andric B Pencic M Pavlovic-kleut V Celic M Pavlovic M Petrovic M Vuleta N Petrovic S Simovic Z Savovic S Milanov G Davidovic V Iric-cupic D Djordjevic M Damjanovic S Zdravkovic V Topic D Stanojevic M Randjelovic R Jankovic-tomasevic V Atanaskovic S Antic D Simonovic M Stojanovic S Stojanovic V Mitic V Ilic D Petrovic M Deljanin Ilic S Ilic V Stoickov S Markovic A Mijatovic D Tanasic G Radakovic J Peranovic N Panic-jelic O Vujadinovic P Pajic S Bekic S Kovacevic A García Fernandez A Perez Cabeza M Anguita L Tercedor Sanchez E Mau J Loayssa M Ayarra M Carpintero I Roldán Rabadan M Gil Ortega A Tello Montoliu E Orenes Piñero S Manzano Fernández A Romero Aniorte A Veliz Martínez M Quintana Giner G Ballesteros M Palacio O Alcalde I García-bolao V Bertomeu Gonzalez F Otero-raviña J García Seara J Gonzalez Juanatey N Dayal P Maziarski P Gentil-baron M Koç E Onrat I Dural K Yilmaz B ÖZin S Tan Kurklu Y Atmaca U Canpolat L Tokgozoglu A Dolu B Demirtas D Sahin O Ozcan Celebi G Gagirci U Turk H Ari N Polat N Toprak M Sucu O Akin Serdar A Taha Alper A Kepez Y Yuksel A Uzunselvi S Yuksel M Sahin O Kayapinar T Ozcan H Kaya M Yilmaz M Kutlu M Demir C Gibbs S Kaminskiene M Bryce A Skinner G Belcher J Hunt L Stancombe B Holbrook C Peters S Tettersell A Shantsila K Senoo K Russell P Domingos S Hussain J Partridge R Haynes S Bahadur R Brown S Mcmahon J Mcdonald K Balachandran R Singh S Garg H Desai K Davies W Goddard G Galasko I Rahman Y Chua O Payne S Preston O Brennan L Pedley C Whiteside C Dickinson J Brown K Jones L Benham R Brady L Buchanan A Ashton H Crowther H Fairlamb S Thornthwaite C Relph A Mcskeane U Poultney N Kelsall P Rice T Wilson M Wrigley R Kaba T Patel E Young J Law C Runnett H Thomas H Mckie J Fuller S Pick A Sharp A Hunt K Thorpe C Hardman E Cusack L Adams M Hough S Keenan A Bowring J Watts J Zaman K Goffin H Nutt Y Beerachee J Featherstone C Mills J Pearson L Stephenson S Grant A Wilson C Hawksworth I Alam M Robinson S Ryan R Egdell E Gibson M Holland D Leonard B Mishra S Ahmad H Randall J Hill L Reid M George S Mckinley L Brockway W Milligan J Sobolewska J Muir L Tuckis L Winstanley P Jacob S Kaye L Morby A Jan T Sewell C Boos B Wadams C Cope P Jefferey N Andrews A Getty A Suttling C Turner K Hudson R Austin S Howe R Iqbal N Gandhi K Brophy P Mirza E Willard S Collins N Ndlovu E Subkovas V Karthikeyan L Waggett A Wood A Bolger J Stockport L Evans E Harman J Starling L Williams V Saul M Sinha L Bell S Tudgay S Kemp L Frost T Ingram A Loughlin C Adams M Adams F Hurford C Owen C Miller D Donaldson H Tivenan H Button A Nasser O Jhagra B Stidolph C Brown C Livingstone M Duffy P Madgwick P Roberts E Greenwood L Fletcher M Beveridge S Earles D Mckenzie D Beacock M Dayer M Seddon D Greenwell F Luxton F Venn H Mills J Rewbury K James K Roberts L Tonks D Felmeden W Taggu A Summerhayes D Hughes J Sutton L Felmeden M Khan E Walker L Norris L O'donohoe A Mozid H Dymond H Lloyd-jones G Saunders D Simmons D Coles D Cotterill S Beech S Kidd B Wrigley S Petkar A Smallwood R Jones E Radford S Milgate S Metherell V Cottam C Buckley A Broadley D Wood J Allison K Rennie L Balian L Howard L Pippard S Board T Pitt-kerby

subject

Adult Male Acute coronary syndrome medicine.medical_specialty medicine.drug_class Hemorrhage Outcomes 030204 cardiovascular system & hematology Lower risk Risk Assessment [SHS]Humanities and Social Sciences 03 medical and health sciences 0302 clinical medicine Fibrinolytic Agents Risk Factors Physiology (medical)Internal medicine Cause of Death Antithrombotic Medicine Humans 030212 general & internal medicine Prospective Studies Registries Practice Patterns Physicians'Stroke Aged EORP-AF registry Aged 80 and over Antithrombotic therapy business.industry Proportional hazards model Atrial fibrillation Vitamin K antagonist Middle Aged medicine.disease Atrial fibrillation Observational registries Europe Stroke Female Cardiology and Cardiovascular Medicine business Antithrombotic therapy; Atrial fibrillation; EORP-AF registry; Observational registries; Outcomes; Stroke Fibrinolytic agent Follow-Up Studies

description

Aims In recent years, stroke prevention in patients with atrial fibrillation (AF) has radically changed, with increasing use of non-vitamin K antagonist oral anticoagulants (NOACs). Contemporary European data on AF thromboprophylaxis are needed. Methods and results We report 1-year follow-up data from the EURObservational Research Programme in Atrial Fibrillation (EORP-AF) General Long-Term Registry. Outcomes were assessed according to antithrombotic therapy. At 1-year follow-up, 9663 (88.0%) patients had available data for analysis: 586 (6.1%) were not treated with any antithrombotic; 681 (7.0%) with antiplatelets only; 4066 (42.1%) with vitamin K antagonist (VKA) only; 3167 (32.8%) with NOACs only; and 1163 (12.0%) with antiplatelet and oral anticoagulant. At 1-year follow-up, there was a low rate of stroke (0.7%) and any thromboembolic event (TE) (1.2%), while haemorrhagic events occurred in 222 patients (2.3%). Cardiovascular (CV) death and all-cause death occurred in 3.9% and 5.2% of patients, respectively. Cumulative survival for all the three main outcomes considered was highest amongst patients treated only with NOACs (P &lt; 0.0001). Multivariable-adjusted Cox regression analysis found that VKA or NOACs use was independently associated with a lower risk for any TE/acute coronary syndrome/CV death, while all treatments were independently associated with a lower risk for CV death and all-cause death. Conclusion The 1-year follow-up of EORP-AF General Long-Term Registry reported a low occurrence of thromboembolic and haemorrhagic events, although mortality was high. Both VKA and NOACs were associated with a lower risk of all main adverse outcomes. All treatments were associated with a lower risk for CV death and all-cause death.

year	journal	country	edition	language
2019-07-01

10.1093/europace/euz032 http://hdl.handle.net/11573/1293388