6533b7dafe1ef96bd126f6ce
RESEARCH PRODUCT
LDL size and subclasses in patients with abdominal aortic aneurysm
Giovam Battista RiniPierre-alex KrayenbühlRizzo ManfrediKaspar BerneisA. FrasheriVincenzo Pernicesubject
medicine.medical_specialtySmall dense ldl610 Medicine & healthmacromolecular substancesDense LDLSmallLDL sizeGastroenterology2705 Cardiology and Cardiovascular MedicineAortic aneurysmInternal medicinePlasma lipidsmedicineIn patientcardiovascular diseasesbusiness.industrymedicine.diseaseAbdominal aortic aneurysmEndocrinologymedicine.anatomical_structureMale patientcardiovascular systemAbdominal aortic aneurysmAbdomenlipids (amino acids peptides and proteins)10029 Clinic and Policlinic for Internal MedicineaterosclerosiCardiology and Cardiovascular MedicinebusinessDyslipidemiadescription
Abstract Since the type of dyslipidemia in patients with abdominal aortic aneurysm (AAA) is still insufficiently defined, we measured plasma lipids and analyzed LDL size and subclasses by gradient gel electrophoresis in 30 male patients (69±6 years, BMI: 27±3) with newly diagnosed AAA and in 26 age- and BMI-matched male healthy controls. Patients with AAA had lower HDL-cholesterol ( p p =.0002) and smaller LDL size ( p p =.0210) in relation to controls. Multivariate analysis also showed that small LDL size was independently associated with the presence of AAA ( p =.0350). Increased levels of small, dense LDL may therefore represent a common feature in patients with AAA.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |