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RESEARCH PRODUCT
Clinical and Brain Imaging Findings in a Child with Vitamin B12 Deficiency
Francesca IncandelaMaria BellizziRoberto FranceschiPaola FeracoCesare Gagliardosubject
Pediatricsmedicine.medical_specialtyMalabsorptionmagnetic resonance imaging (MRI)business.industryRSettore MED/37 - Neuroradiologianutritional and metabolic diseasesCase ReportVegan Dietvitamin B12medicine.diseasePediatricsRJ1-570AtrophyNeuroimagingFailure to thriveMedicineMedicineBrain magnetic resonance imagingVitamin B12medicine.symptombusinessAfter treatmentbrain atrophydescription
Vitamin B12 (Vit-B12) deficiency is a rare and treatable cause of failure to thrive and delayed development in infants who are exclusively breastfed. Apart from genetic causes, it can be related to a malabsorption syndrome or when the mother follows a strict vegetarian or vegan diet, causing a low hepatic storage of Vit-B12 in the infant at birth. As the neurological symptoms are nonspecific, a brain magnetic resonance imaging (MRI) exam is usually performed to rule out primary causes of neurodevelopmental delay. Findings related to brain atrophy are usually observed. A favorable response is achieved with Vit-B12 therapy, and neurological symptoms dramatically improve within a few days after the treatment. We present the case of an infant with severe Vit-B12 deficiency, exclusively breastfed by his young vegan mother, and whose clinical symptoms together with MRI findings improved after treatment. Brain atrophy recovery after Vit-B12 therapy has been seldom documented.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-10-01 |