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RESEARCH PRODUCT

[Central blood pressure and vascular damage].

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Abstract Background and objective The aim of this study was to assess the relationship between central blood pressure and vascular damage. Patients and methods This cross-sectional study involved 393 never treated hypertensive patients (166 women). Clinical blood pressure (BP), 24 h blood pressure (BP 24 h ) and central blood pressure (CBP) were measured. Vascular organ damage (VOD) was assessed by calculating the albumin/creatinine ratio (ACR), wave pulse pressure velocity and echocardiographic left ventricular mass index (LVMI). Results Patients with VOD had higher values of BP, BP 24 h , and CBP than patients without ACR. When comparing several systolic BP, systolic BP 24 h had a higher linear correlation with CBP (Z Steiger test: 2.26; P  = .02) and LVMI (Z Steiger test: 3.23; P  = .01) than PAC. In a multiple regression analysis corrected by age, sex and metabolic syndrome, all pressures were related with VOD but systolic BP 24 h showed the highest correlation. In a logistic regression analysis, having the highest tercile of systolic BP 24 h was the stronger predictor of VOD (multivariate odds ratio: 3.4; CI 95%: 2.5–5.5, P  = .001). Conclusions CBP does not have more correlation with VOD than other measurements of peripheral BP. Systolic BP 24 h is the BP measurement that best predicts VOD.