6533b7dbfe1ef96bd126ffed

RESEARCH PRODUCT

Polychlorinated biphenyls affect histone modification pattern in early development of rats: a role for androgen receptor-dependent modulation?

Alessandra ColciagoLavinia CasatiManel EstellerFabio CelottiMaría BerdascoPaola Negri-cesiRamon Sendra

subject

MaleCancer Researchmedicine.medical_specialtyJumonji Domain-Containing Histone DemethylasesTranscription GeneticEnvironmental pollutionMethylationEpigenesis GeneticHistonesRats Sprague-DawleySirtuin 1PregnancyInternal medicineGeneticsmedicineAnimalsHumansEpigeneticsReceptorbiologyEpigenomeDNA MethylationPolychlorinated BiphenylsRatsAndrogen receptorEndocrinologyHistoneHEK293 CellsLiverSex steroidReceptors AndrogenPrenatal Exposure Delayed Effectsbiology.proteinH3K4me3CpG IslandsEnvironmental PollutantsFemale

description

Background: The epigenome represents an important target of environmental pollution. Early-life exposure to polychlorinated biphenyls (PCBs) modifies sex steroid enzymes and receptor transcription patterns. Steroid receptors, such as androgen receptor (AR), function as coregulators of histone modification enzymes. Aim: To clarify if a PCB early-life exposure might affect the epigenome in rat liver, we analyzed some histone post-translational modifications (H3K4me3 and H4K16Ac) and the corresponding histone remodeling enzymes, and the AR as a histone enzyme coregulator. Results: We observed a decrease of H4K16Ac and H3K4me3 levels, possibly linked to the induction of chromatin-modifying enzymes SirtT1 and Jarid1b, and a decrease of AR. PCBs also seem to induce AR transcriptional activity. Some of the observed effects are sex dimorphic. Conclusion: Our data suggest that an early-life exposure to PCB sometimes modifies the epigenome in the offspring liver in a dimorphic way. AR might be involved in modulating PCB effects on the epigenome.

yearjournalcountryeditionlanguage
2012-02-16Epigenomics
10.2217/epi.11.110https://pubmed.ncbi.nlm.nih.gov/22332662