6533b7dbfe1ef96bd1270858

RESEARCH PRODUCT

Intravenous Use of Methadone: Efficacy and Safety

Sebastiano Mercadante

subject

business.industryChronic painPerioperativemedicine.diseaseIntravenous usePharmacokineticsAnesthesiaToxicitymedicineOral routeCancer painbusinessMethadonemedicine.drug

description

Parenteral methadone could be helpful in specific conditions, particularly in unstable conditions of when the oral route is unavailable. Intravenous methadone should be the preferred parenteral route, due to concerns about the local toxicity of subcutaneous route. This chapter assesses aspects regarding the pharmacokinetic issues, the clinical use, the problems associated with the use of intravenous methadone for chronic pain, as well as the perioperative use of intravenous methadone.

yearjournalcountryeditionlanguage
2013-01-01
https://doi.org/10.1007/978-1-4614-6974-2_8