6533b7dbfe1ef96bd127092b

RESEARCH PRODUCT

Hierarchical Imprinting Using Crude Solid Phase Peptide Synthesis Products as Templates

Andy HallMaria-magdalena TitiriciBörje Sellergren

subject

chemistry.chemical_classificationGeneral Chemical EngineeringPeptideGeneral ChemistryEpitopechemistry.chemical_compoundChromatographic separationTemplateAffinity chromatographychemistryMaterials ChemistryPeptide synthesisOrganic chemistryImprinting (psychology)Molecular imprinting

description

The crude products resulting from solid-phase peptide synthesis can be used as epitope templates to generate surface-confined sites for the template and larger peptides containing the template motif. This offers a facile route to robust affinity stationary phases for the chromatographic separation of peptides.

https://doi.org/10.1021/cm025770j