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RESEARCH PRODUCT
Enantioselective Synthesis of 4-Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes
Amparo Sanz-marcoM. Carmen MuñozGonzalo BlayJosé R. Pedrosubject
Nucleophilic additionChemistryStereochemistryN O ligandsEnantioselective synthesischemistry.chemical_elementAlkynylationGeneral ChemistryZincCatalysisOxygen heterocyclesAlkynylationFISICA APLICADAAsymmetric catalysismedia_common.cataloged_instanceEuropean unionNucleophilic additionmedia_commonConjugatedescription
A new enantioselective catalyst for the conjugate addition of terminal alkynes has been developed. Terminal alkynes react with 3-alkoxycarbonylcoumarins in the presence of diethylzinc and bis(hydroxyamide) ligands to give chiral non-racemic dihydrocoumarins substituted with an alkynyl group on the C-4 position with good yields and enantiomeric excesses up to 95%.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-04-15 | Advanced Synthesis & Catalysis |