6533b7dbfe1ef96bd1270ab9
RESEARCH PRODUCT
Metabolic connectivity as index of verbal working memory
Dmitry TitovIgor YakushevAndreas FellgiebelMustafa Gokce BaydoganJing LiFlorian U. FischerGaël ChételatMathias SchreckenbergerJuergen DukartJuergen DukartNa Zousubject
AdultMaleModels Anatomicmedicine.medical_specialtyAudiologyEstimation of covariance matricesYoung AdultNeuroimagingFluorodeoxyglucose F18medicineHumansAnalysis of covarianceResting state fMRImedicine.diagnostic_testWorking memoryBrainCognitionIntensity (physics)Memory Short-TermNeurologyPositron emission tomographyPositron-Emission TomographyOriginal ArticleFemaleNeurology (clinical)Nerve NetCardiology and Cardiovascular MedicinePsychologySocial psychologydescription
Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [18F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-03-18 |