6533b7dbfe1ef96bd1270bdf

RESEARCH PRODUCT

A Short and Improved Synthesis of the Antiprotozoal Abietane Diterpenoid (–)-Sugikurojin A

Ramón J. ZaragozáMiguel A. González-cardenete

subject

0301 basic medicineBiological studiesChemistrymedicine.drug_classTerpenoidsAcylation030106 microbiologyOrganic ChemistrySandaracSemisynthesisCatalysisTerpenoidCallitrisic acidAcylation03 medical and health scienceschemistry.chemical_compoundYield (chemistry)AbietanesAntiprotozoalmedicineOrganic chemistrySemisynthesisAbietane

description

An efficient and straightforward semisynthesis of the antiprotozoal abietane diterpenoid (–)-sugikurojin A, starting from the readily available methyl ester of callitrisic acid (4-epi-dehydroabietic acid­) isolated from sandarac resin, is reported. This optimized semi­synthetic route provides a convenient source of the antiprotozoal compound, in four steps from methyl callitrisate in 50% overall yield, for further biological studies.

yearjournalcountryeditionlanguage
2016-11-28
10.1055/s-0036-1588353http://hdl.handle.net/10261/164456